RESEARCH Assistant Professor

电话: (757) 683-7027

电子邮件: isemenov@gypsyleina.com, iurii.semenov@gmail.com

地址: IRP 2, 4211 Monarch Way, 诺福克, VA, 23508

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Education

• Postdoctoral RESEARCH fellow:

  2003 - 2006: Postdoctoral Fellow, Department of Physiology, University of Texas 健康 Science Center at San Antonio, 7703弗洛伊德·柯尔博士., San Antonio TX 78229, USA

  2006 - 2008: Postdoctoral Fellow, Department of Biochemistry, University of Texas 健康 Science Center at San Antonio, 7703弗洛伊德·柯尔博士., San Antonio TX 78229, USA

  2008 - 2009: 访问ing RESEARCH Specialist, Department of Medicine, Section of Cardiology, University of Illinois at Chicago, 840 S. 木圣., Chicago, IL 60612, USA

  2009 - 2011: Postdoctoral RESEARCHer, Department of Physiology, University of Texas 健康 Science Center at San Antonio, 7703弗洛伊德·柯尔博士., San Antonio TX 78229, USA

  2012 - 2013: Postdoctoral RESEARCHer, Frank Reidy RESEARCH Center for 生物, Old Dominion University 4211 Monarch Way, 318套房, 诺福克, VA 23508

• 博士: Taras Shevchenko Kyiv National University, Biological 教师. Volodymyrska Str. 64, Kyiv, Ukraine, 01033, 2002
• M.S: Taras Shevchenko Kyiv National University, Biological 教师. Volodymyrska Str. 64, Kyiv, Ukraine, 01033, 1996

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RESEARCH Description

My research interests are focused on intracellular effects of nanosecond pulsed electric fields (nsPEFs), particularly on how function of the cells of different types can be manipulated using nsPEFs. I also investigate nsPEF effects on molecular mechanisms of intracellular calcium regulation and signal-transduction pathways in the excitable and non-excitable cells. Our team revealed that nanosecond stimuli can mimic natural Ca2+ signaling while bypassing the usual receptor- and channels-mediated cascades. The recruitment of the intracellular Ca2+ can be controlled by the duration of the stimulus. We also reported a novel phenomenon of bioeffects cancellation observed when secondary nanosecond pulse of the same strength and duration, but opposite polarity, follows closely after the first pulse. It puts nanosecond electric pulses apart from the conventional electroporation and 电刺激 by milli- and microsecond pulses.

I work in tight collaboration with Prof. Pakhomov and take a part in the projects devoted to bipolar cancellation and nsPEF defibrillation of a heart. These research efforts are supported by MURI grant from AFOSR, an RO1 grant from NIH.

Most relevant publications

1. Pakhomov A, Gudvangen E, 肖年代, Semenov我. Interference targeting of bipolar nanosecond electric pulses for spatially focused electroporation, 电刺激, and tissue ablation. Bioelectrochemistry. 2021 Jun 15;141:107876. doi: 10.1016/j.bioelechem.2021.107876.
2. Semenov我, Grigoryev S, Neuber JU, Zemlin CW, Pakhomova ON, Casciola M, Pakhomov AG. Excitation and injury of adult ventricular cardiomyocytes by nano- to millisecond electric shocks. Sci代表. 2018 May 29;8(1):8233. doi: 10.1038/s41598-018-26521-2.
3. Semenov我, 肖年代, 康D, Schoenbach KH, Pakhomov AG Cell stimulation and calcium mobilization of by picosecond electric pulses. Bioelectrochemistry. 2015年10月,105:65 - 71.
4. Semenov我, 肖年代, Pakhomova ON, Pakhomov AG. Recruitment of the intracellular Ca2+ by ultrashort electric stimuli: the impact of pulse duration. 细胞钙. 2013 Sep;54(3):145-50. doi: 10.1016/j.盲肠.2013.05.008. Epub 2013年6月15日.
5. Semenov我, 肖年代, Pakhomov AG. Primary pathways of intracellular Ca(2+) mobilization by nanosecond pulsed electric field. Biochim Biophys Acta. 2013 Mar;1828(3):981-9. doi: 10.1016/j.bbamem.2012.11.032. 2012年12月5日.